Year : 2016 | Volume
: 10 | Issue : 1 | Page : 18--24
Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block
Safaa M Helal1, Ashraf M Eskandr1, Khaled M Gaballah1, Ihab S Gaarour2
1 Department of Anesthesiology, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia, Egypt
2 Department of Anesthesiology, King Fahd Hospital of the University of Dammam, Al Khobar, Saudi Arabia
Background and Aim: Perineural administration of dexmedetomidine, a α2-adrenoceptor agonist, prolongs the duration of analgesia. We hypothesized that adding dexmedetomidine to bupivacaine would prolong postoperative analgesia after below knee surgery.
Materials and Methods: After ethical approval, 60 patients scheduled for below knee surgery under combined femoral-sciatic nerve block were randomly allocated into two groups to have their block performed using bupivacaine 0.5% alone (group B) or bupivacaine 0.5% combined with 100 μg bupivacaine-dexmedetomidine (group BD). Motor and sensory block onset times; durations of blockades and analgesia were recorded.
Results: Sensory and motor block onset times were shorter by 20% in group BD than in group B (P < 0.01). Sensory and motor blockade durations were longer in group BD (+45% and +40%, respectively) than in group B (P < 0.01). Duration of analgesia was longer in group BD by 75% than in group B (P < 0.01). Systolic, diastolic arterial blood pressure levels, and heart rate were significantly less in group BD, six patients in group BD, and no patients in group B developed bradycardia (P < 0.05).
Conclusion: The addition of dexmedetomidine 100 μg to bupivacaine 0.5% during ultrasound-guided combined femoral and sciatic block for below knee surgery was associated with a prolonged duration of analgesia. However, this may be associated with significant bradycardia requiring treatment.
Ihab S Gaarour
Department of Anesthesiology, King Fahd Hospital of the University of Dammam, Al Khobar, P.O. 40124, Al Khubar 31952
|How to cite this article:|
Helal SM, Eskandr AM, Gaballah KM, Gaarour IS. Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block.Saudi J Anaesth 2016;10:18-24
|How to cite this URL:|
Helal SM, Eskandr AM, Gaballah KM, Gaarour IS. Effects of perineural administration of dexmedetomidine in combination with bupivacaine in a femoral-sciatic nerve block. Saudi J Anaesth [serial online] 2016 [cited 2021 May 12 ];10:18-24
Available from: https://www.saudija.org/article.asp?issn=1658-354X;year=2016;volume=10;issue=1;spage=18;epage=24;aulast=Helal;type=0