Previous article Table of Contents  Next article

Year : 2022  |  Volume : 16  |  Issue : 4  |  Page : 430-436

Effect of two different levels of positive end-expiratory pressure (PEEP) on oxygenation and ventilation during pneumoperitoneum for laparoscopic surgery in children: A randomized controlled study

1 Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Anesthesiology, and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Soumya Sarkar
Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar - 751 019, Odisha
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sja.sja_445_22

Rights and Permissions
Date of Submission14-Jun-2022
Date of Acceptance14-Jul-2022
Date of Web Publication03-Sep-2022


Background: Positive end-expiratory pressure (PEEP) is used to attenuate the changes in respiratory parameters because of pneumoperitoneum during laparoscopic (LAP) surgery. As the ideal level of PEEP during LAP in children is not known, this study compared the effect of 5- and 10–cm H2O of PEEP on oxygenation, ventilator, and hemodynamic parameters during pediatric LAP.
Method: After obtaining approval from the Institute Ethics Committee and written informed parental consent, 30 American Society of Anesthesiologists (ASA) I and II children aged 2–10 years, undergoing LAP were randomized to receive PEEP of 5- or 10–cm H2O during pneumoperitoneum. Baseline hemodynamic and ventilatory parameters, PaO2, and PaCO2 were measured 2 min after tracheal intubation, 2 min and 1 h after pneumoperitoneum, and after deflation of pneumoperitoneum. Oxygenation index, dynamic compliance, and alveolar-arterial oxygen gradient (D (A-a) O2) were calculated at the above-mentioned time points. Data were analyzed using Student's t-test and repeated measures ANOVA with Bonferroni correction.
Results: The oxygenation index and D(A-a)O2 decreased in PEEP 5 Group and increased in PEEP 10 Group after pneumoperitoneum, the difference between the two groups being statistically significant (P = 0.001). The dynamic compliance decreased in PEEP 5 Group and increased or remained the same in PEEP 10 Group after pneumoperitoneum, the difference between the two groups being significant (P = 0.001). There were no significant changes in the hemodynamic parameters in the two groups.
Conclusion: Use of 10-cm H2O PEEP during pneumoperitoneum in children improves ventilation and oxygenation, without significant hemodynamic changes.

Keywords: Alveolar-arterial oxygen gradient, dynamic compliance, laparoscopic surgery, oxygenation index, positive-end-expiratory pressure

How to cite this article:
Bhardwaj N, Sarkar S, Yaddanapudi S, Jain D. Effect of two different levels of positive end-expiratory pressure (PEEP) on oxygenation and ventilation during pneumoperitoneum for laparoscopic surgery in children: A randomized controlled study. Saudi J Anaesth 2022;16:430-6

How to cite this URL:
Bhardwaj N, Sarkar S, Yaddanapudi S, Jain D. Effect of two different levels of positive end-expiratory pressure (PEEP) on oxygenation and ventilation during pneumoperitoneum for laparoscopic surgery in children: A randomized controlled study. Saudi J Anaesth [serial online] 2022 [cited 2022 Dec 1];16:430-6. Available from:

  Introduction Top

Laparoscopic (LAP) surgery has emerged as the treatment modality of choice not only in adults but also in pediatric patients because of its many advantages over conventional surgery.[1],[2],[3],[4],[5] Carbon dioxide (CO2) pneumoperitoneum, an integral component of LAP surgery, decreases functional residual capacity (FRC) and dynamic compliance (Cdyn), causing atelectasis and an increase in ventilation–perfusion (V/Q) mismatch.[6] Children are prone to develop more hypercarbia, acidosis, and hypoxia during pneumoperitoneum because of smaller airway caliber, increased shunt, and dead space ventilation.[7],[8],[9] Positive end-expiratory pressure (PEEP) has been used to attenuate the decrease in partial pressure of arterial oxygen (PaO2) that accompanies pneumoperitoneum. However, in children, there is no consensus regarding the ideal level of PEEP for improving oxygenation without adverse effects.

It has been found in children that during LAP appendectomy, pressure-controlled ventilation (PCV) with 5-cm H2O PEEP provides better dynamic compliance in comparison to volume-controlled ventilation (VCV) with 5-cm H2O PEEP.[10] However, there has been no comparison of the effect of various levels of PEEP on oxygenation and dynamic compliance in children. Based on the previous study of Sen and Erdogan Doventas[8] in adult LAP cholecystectomy, this study hypothesized that during pneumoperitoneum, 10-cm H2O PEEP would provide better compliance and oxygenation, without significant hemodynamic and respiratory complications in comparison to 5-cm H2O PEEP.

The primary objective of this study was to compare and assess the effect of 5- and 10-cm H2O PEEP on oxygenation index, and the secondary outcomes were assessment of ventilation and hemodynamic parameters in children undergoing LAP surgery under general anesthesia (GA).

  Materials and Methods Top

This prospective single-blinded randomized study was conducted after institutional ethics committee approval (INT/IEC/2017/1245), registration in Clinical Trials Registry of India (CTRI/2017/11/010592), and written informed parental consent and patient assent in 36, American Society of Anesthesiologists (ASA) physical status I or II children, aged 2–10 years undergoing LAP surgeries. Children with an anticipated difficult airway, acute respiratory tract infection, and any cardiopulmonary disease were excluded. The patients were randomly allocated to receive either external PEEP of 5-cm H2O (n = 18) or 10-cm H2O (n = 18) using and simple randomization. A serially numbered opaque sealed envelope method was used for the concealment of random allocation. The investigators were aware of the allocated group, but participants and data analysts were blinded to group allocation.

Anesthesia management

The children received premedication with 0.5 mg/kg of oral midazolam about 30 min before surgery. They were pre-oxygenated with 100% oxygen and anesthesia was induced with sevoflurane at a fresh gas flow of 4 L/min. Intubation was done with an appropriate size-cuffed endotracheal tube (ETT) after administering atracurium (0.5 mg/kg). Anesthesia was maintained with oxygen in the air (FiO2 0.5) and isoflurane (MAC >1.1) and morphine 0.1 mg/kg was administered to provide analgesia. Immediately after intubation, an arterial cannula preferably in the radial artery was placed for arterial blood gas analysis.

All children received identical ventilation after induction of anesthesia consisting of PCV with an I: E ratio of 1:2. Peak airway pressure (Ppeak) was set initially to deliver a tidal volume (VT) of 8 ml/kg and then changed after pneumoperitoneum with an intra-abdominal pressure (IAP) of 10 mmHg in supine position to match the baseline-expired VT. The respiratory rate (RR) was adjusted to maintain the end-tidal carbon dioxide (ETCO2) between 35 and 40 mmHg. PEEP of 5- or 10-cm H2O was added after pneumoperitoneum as per the group allocation.

Intraoperative monitoring included ECG, non-invasive blood pressure (NIBP), oxygen saturation (SpO2), and ETCO2. Ventilatory parameters, such as Ppeak, mean airway pressure (Pmean), RR, and VT were recorded from the ventilator. Cdyn was calculated as VT/(Ppeak – PEEP). An arterial blood sample was taken to measure PaO2, PaCO2, and pH at T1 (Baseline value after intubation), T2 (2 min after pneumoperitoneum with an IAP of 12 mmHg), T3 (60 min after application of PEEP during pneumoperitoneum), and T4 (after deflation of pneumoperitoneum) time points. From these readings, oxygenation index (PaO2/FiO2) and alveolar-arterial oxygen gradient (PAO2–PaO2) were calculated. The alveolar PO2 (PAO2) was measured using the alveolar gas equation.

Ondansetron (0.15 mg/kg) was administered at the end of surgery for prophylaxis against postoperative nausea and vomiting (PONV). Residual neuromuscular blockade was reversed with neostigmine (0.05 mg/kg) and glycopyrrolate (0.01 mg/kg). The patients were monitored in the Post-Anesthesia Care Unit for pain, heart rate (HR), NIBP, SpO2, and PONV.

Sample size calculation

The sample size was estimated based on the findings of a study by Sen and Erdogan Doventas[8] in which the PEEP 10 Group had a mean PaO2 of 176.1 (37.9) mmHg after 30 min of pneumoperitoneum, whereas in the PEEP 5 Group, the mean PaO2 was 135.2 (36.9) mmHg. To detect the same difference in PaO2, with 80% power and α error of 0.05, a sample size of 14 per group was calculated. To adjust for attrition, a total of 36 children were enrolled.

Statistical analysis

The results were analyzed by the Windows Program SPSS 15.0. Descriptive statistics were provided in terms of numbers and percentages for categorical variables and in terms of the mean and standard deviation for continuous variables. The variables were compared between the two groups using the Student's t-test (continuous variables) and Chi-square test (categorical variables). Within-group comparison at different time points was done by Repeated Measures ANOVA with Bonferroni correction. Statistical significance level was accepted with a P value less than 0.05.

  Results Top

Thirty-six patients were enrolled and randomized in this study. Six patients were excluded as LAP surgery was converted to open surgery on three occasions and the duration of surgery was less than 60 min in three instances. Finally, data from 30 patients were analyzed with 15 patients in each group [Figure 1], [Table 1]. The demographic parameters are shown in [Table 2].
Figure 1: CONSORT flow chart

Click here to view
Table 1: Surgical procedures performed in both the groups

Click here to view
Table 2: Demographic variables

Click here to view

The oxygenation index decreased in PEEP 5 Group and increased in PEEP 10 Group after the creation of pneumoperitoneum, the difference between the two groups being statistically significant [Table 2], [Figure 2]a. The oxygenation index continued to be low immediately after deflation of pneumoperitoneum in the PEEP 5 Group [Figure 3]a. The dynamic compliance decreased in PEEP 5 Group and increased or remained the same in PEEP 10 Group after pneumoperitoneum [Figure 3]b, the difference between the two groups being significant [Figure 2]b. The alveolar-arterial oxygen gradient increased [Figure 3]c and arterial oxygen tension decreased [Figure 3]d in PEEP 5 Group after pneumoperitoneum, and reverse changes occurred in PEEP 10 Group, with the differences between the two groups being significant [Figure 2]c.
Figure 2: (a) Mean difference in oxygenation index compared from baseline (b) mean difference in dynamic compliance compared from baseline (c) mean difference in alveolar-arterial oxygen gradient compared from baseline

Click here to view
Figure 3: (a) PaO2/FiO2 – oxygenation index mean (SD) at different time points (b) Dynamic compliance mean (SD) at different time points (c) Alveolar-arterial oxygen gradient mean (SD) at different time points (d) PaO2 mean (SD) at different time points (e) PaCO2 mean (SD) at different time points (f) Peak airway pressure mean (SD) at different time points (g) Mean airway pressure mean (SD) at different time points (h) Heart rate mean (SD) at different time points. (i) Mean arterial pressure mean (SD) at different time points. #(P<0.05) intergroup comparison using Students t Test; *(P<0.05) within group comparison using Repeated Measure ANOVA with Bonferroni correction

Click here to view

In both PEEP 5 and PEEP 10 Groups the peak [Figure 3]f and mean [Figure 3]g airway pressures increased significantly at T2 (P = 0.02), T3 (P = 0.001) and T4 (P = 0.015, 0.007) time points when compared to baseline.

There were no significant differences in the PaCO2 [Figure 3]e, HR [Figure 3]h, and mean arterial pressure (MAP) [Figure 3]i in the two groups after pneumoperitoneum [Table 3], [Supplementary Table 1].
Table 3: Changes from baseline (T1) at different times after pneumoperitoneum

Click here to view

  Discussion Top

This study demonstrated that PCV with the application of 10-cm H2O PEEP during pneumoperitoneum facilitates better oxygenation and ventilation in children undergoing LAP procedures without any significant hemodynamic changes.

Carbon dioxide pneumoperitoneum causes an increase in IAP, airway pressure, and ETCO2 tension. The cephalic shift of the diaphragm during pneumoperitoneum reduces FRC by inducing basal lung collapse. It increases intrapulmonary shunt, the alveolar-arterial oxygen tension gradient, and V/Q mismatch.[9] Bannister et al.[6] also reported a decrease in Cdyn by 48%, a reduction in VT delivery by 33% with raised ETCO2 by 13%, and a fall in oxygen saturation by 41% in infants undergoing LAP procedures.

Multiple ventilatory strategies have been introduced to minimize the respiratory and hemodynamic effects of carbon dioxide pneumoperitoneum during LAP. VCV guarantees delivery of targeted TV with the risk of increased airway pressures. On the other hand, PCV delivers an appropriate volume, independent of circuit compliance, changes in the fresh gas flow, and leaks around ETT by using a decelerating flow, which compensates for any potential reduction in ventilation caused by pressure limitation. It enables a more homogenous distribution of the VT in all ventilated alveoli, reducing the amount of atelectasis by improved alveolar recruitment.[7] The airway pressure also rises significantly during pneumoperitoneum. In this situation, PCV is theoretically preferred as the Ppeak is limited and there is a lesser chance of barotrauma. In a study on children undergoing LAP appendectomy, significantly higher dynamic compliance and Pmean were demonstrated with the use of PCV with 5-cm H2O PEEP compared to VCV with 5-cm H2O PEEP.[7] This study, therefore, used PCV as the ventilatory mode on children undergoing LAP surgeries.

Depending on the degree of PEEP used, PCV during LAP produces different ventilatory effects. PEEP improves pulmonary compliance, ventilation–perfusion abnormalities, and pulmonary oxygen exchange by preventing the collapse or closure of airways and redistributing the pulmonary blood flow.[10],[11] By keeping the airway open at the end of the expiratory period, PEEP helps in maintaining adequate gas exchange.[12] The increase in Ppeak and Pmean leads to decreases in dynamic compliance during pneumoperitoneum. In the Trendelenburg position, these changes became more prominent.[6],[13] It has been established in different studies that the application of PEEP improves oxygenation during LAP surgery under GA. This study also showed the benefit of the application of PEEP in terms of oxygenation and dynamic compliance. However, there is no consensus in the literature regarding the ideal amount of PEEP that should be used for optimum benefit.

Various authors have found 10-cm H2O PEEP to be beneficial in terms of oxygenation without hemodynamic complications in adults.[8],[14],[15] Lee et al.[14] found that PEEP of 10-cm H2O resulted in higher oxygenation compared to those with lower PEEP levels in adult patients undergoing robot-assisted LAP radical prostatectomy. Sen and Erdogan Doventas also concluded that PEEP of 10-cm H2O increases oxygenation and compliance, without hemodynamic and respiratory complications, compared to a PEEP of 5-cm H2O during LAP cholecystectomy.[8] In another study, the application of 10-cm H2O PEEP helped in obtaining a better oxygenation index and CO2 elimination during LAP cholecystectomy compared to 0- and 5-cm H2O PEEP, without any significant hemodynamic changes.[15] Schibler et al.[12] described better preservation of FRC with 10 PEEP [302.2 (160.4)] in comparison to application of 5 PEEP [280.0 (201.1) and no PEEP 256.9 (178.6)] with better homogenous ventilation and improved PaO2 in mechanically ventilated children.

Similar to the above-mentioned studies on adults, the oxygenation index increased significantly during pneumoperitoneum, and after deflation of pneumoperitoneum, compared to the baseline in the PEEP 10 group in this study. On the other hand, in the PEEP 5 group, the oxygenation index decreased at all time points when compared to baseline.

It has been found that in comparison to zero PEEP, application of a PEEP of 10-cm H2O during pneumoperitoneum significantly improves the respiratory system elastance and resistance.[16] An electrical impedance tomographic study during LAP cholecystectomy has shown that recruitment manoeuver and application of 10-cm H2O PEEP provides better respiratory compliance and oxygenation by providing homogenous ventilation distribution in comparison to zero PEEP.[17] A comparative study on 0-, 5-, and 8-cm H2O PEEP during LAP cholecystectomy demonstrated that application of 8-cm H2O PEEP increases compliance and causes less impairment of postoperative pulmonary function compared to 0- and 5-cm H2O PEEP.[18] Similarly, Spadaro et al.[19] found that application of PEEP of 5-cm H2O during LAP surgery is not satisfactory to counterbalance the effect of raised IAP during pneumoperitoneum, compared to 10-cm H2O PEEP. They also described a significant reduction in pulmonary shunts (13% vs 6%; P = 0.001) with only 10-cm H2O PEEP in comparison to zero PEEP.

This study also demonstrated a significant decrease in dynamic compliance during pneumoperitoneum (T2, T3) and after deflation of pneumoperitoneum (T4) compared to baseline (T1) in PEEP 5 group. On the other hand, the compliance in PEEP 10 group improved from baseline during other time points and was better than PEEP 5 group.

In this study during pneumoperitoneum and after deflation, the Ppeak increased from baseline in both groups. But the increase in Ppeak and Pmean were more in PEEP 10 group compared to the PEEP 5 group. This is expected because an increase in PEEP will proportionately increase the Ppeak and Pmean. Sen and Erdogan Doventas also found similar changes in airway pressures during LAP cholecystectomy in the adult population.[8]

The application of PEEP of 10-cm H2O during pneumoperitoneum was associated with the lowest alveolar-arterial oxygen gradient (D (A-a) O2), better ventilation because of the formation of comparatively less atelectasis in the dependent portions of lungs compared to groups with lower level PEEP. The D (A-a) O2 was significantly lower after 1 h of pneumoperitoneum in the PEEP 10 group but no significant changes were noted in other PEEP groups by Lee et al.[14] Similarly in this study, the alveolar-arterial gradient was significantly lower during pneumoperitoneum and after deflation in PEEP 10 group compared to PEEP 5 group.

This study found a significant rise of PaO2 at all the time points from baseline in the PEEP 10 group. On the contrary, it decreased from baseline at other time points in PEEP 5 group. The PaCO2 level increased significantly from baseline at the onset of pneumoperitoneum in both groups and was comparable. A similar significant increase in PaO2 from baseline after 1 h of pneumoperitoneum in the 10 PEEP group was noted by Lee et al.[14] with no significant change in other groups. Sen and Erdogan Doventas found significantly increased PaO2 and decreased PaCO2 in PEEP 10 group compared to PEEP 5 group.[8] However, Lee et al.[14] described an increase in PaCO2 from baseline at the onset of pneumoperitoneum in all the groups. After 3 h of pneumoperitoneum, the PaCO2 levels in the 5, 7, and 10 PEEP groups were significantly higher in comparison to lower PEEP groups. This difference in results may be related to the duration of pneumoperitoneum that was 30 min in the study of Sen and Erdogan Doventas,[8] 3 h in the study of Lee et al.,[14] and was 60 min in this study.

The most common concern for the application of PEEP during LAP surgery is hemodynamic changes and barotrauma. Theoretically, the raised IAP during pneumoperitoneum increases intra-thoracic pressure, thereby decreasing the venous return and cardiac output (CO), and application of PEEP may further worsen the condition. Kundra et al.[15] found no significant difference in HR, MAP, and CO between 0-, 5-, and 10-cm H2O PEEP groups during LAP cholecystectomy. Similarly, Sen and Erdogan Doventas[8] also reported no significant hemodynamic changes associated with the application of PEEP 10 in comparison to the PEEP 5 group. This study population, comprising of healthy ASA I and II children aged 2–10 years, also demonstrated no significant changes in HR and MAP associated with PEEP 10 group in comparison to the PEEP 5 group. There was no incidence of respiratory complications in the patients of this study.


The assessment of outcomes in this study was limited to 1 h of pneumoperitoneum and restricted to intraoperative period only. Assessing the parameters for a longer period would have been more informative.

  Conclusion Top

PCV with 10-cm H2O PEEP during pneumoperitoneum in children aged 2–10 years produces better oxygenation, by maintaining higher compliance and lower alveolar-arterial oxygen gradient, in comparison to 5-cm H2O PEEP.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Holcomb GW, Olsen DO, Sharp KW. Laparoscopic cholecystectomy in the paediatric patient. J Pediatr Surg1991;26:1186-90.  Back to cited text no. 1
Newman KD, Marmon LM, Attorri R, Evans S. Laparoscopic cholecystectomy in paediatric patient. J Paediatric Surg 1991;26:1184-5.  Back to cited text no. 2
Fahy BG, Barnas GM, Flowers JL, Nagle SE, Njoku MJ. The effects of increased abdominal pressure on lung and chest wall mechanics during laparoscopic surgery. Anesth Analg 1995;81:744-50.  Back to cited text no. 3
Baroncini S, Gentili A, Pigna A, Fae M, Tonini C, Tognù A. Anaesthesia for laparoscopic surgery in paediatrics, Minerva Anestesiol 2002;68:406-13.  Back to cited text no. 4
McHoney M, Corizia L, Eaton S, Kiely EM, Drake DP, Tan HL, et al. Carbon dioxide elimination during laparoscopy in children is age dependent. J Pediatri Surg 2003;38:105 – 10.  Back to cited text no. 5
Bannister CF, Brosius KK, Wulkan M. The effect of insufflation pressure on pulmonary mechanics in infants during laparoscopic surgical procedures. Pediatr Anesth 2003;13:785–9.  Back to cited text no. 6
Kim JY, Shin CS, Lee KC, Chang YJ, Kwak HJ. Effect of pressure versus volume controlled ventilation on the ventilatory and hemodynamic parameters during laparoscopic appendectomy in children: Aprospective, randomized study. J Laparoendosc Adv Surg Tech A 2011;21:655–58.  Back to cited text no. 7
Sen O, Erdogan Doventas Y. Effects of different levels of end-expiratory pressure on hemodynamic, respiratory mechanics and systemic stress response during laparoscopic cholecystectomy. Rev Bras Anestesiol 2017;67:28-34.  Back to cited text no. 8
Srivastava A, Niranjan A. Secrets of safe laparoscopic surgery: Anaesthetic and surgical considerations. J Minim Access Surg 2010;6:91-4.  Back to cited text no. 9
Meininger D, Byhahn C, Mierdl S, Westphal K, Zwissler B. Positive end-expiratory pressure improves arterial oxygenation during prolonged pneumoperitoneum. Acta Anaesthesiol Scand 2005;49:778–83.  Back to cited text no. 10
Kim Y, Shin CS, Kim HS, Jung WS, Kwak HJ. Positive end expiratory pressure in pressure-controlled ventilation improves ventilatory and oxygenation parameters during laparoscopic cholecystectomy. Surg Endosc 2010;24:1099–103.  Back to cited text no. 11
Schibler A, Henning R. Positive end-expiratory pressure and ventilation inhomogeneity in mechanically ventilated children. Pediatr Crit Care Med 2002;3:124-8.  Back to cited text no. 12
Neira VM, Kovesi T, Guerra L, Campos M, Barrowman N, Splinter WM. The impact of pneumoperitoneum and Trendelenburg positioning on respiratory system mechanics during laparoscopic pelvic surgery in children: A prospective observational study. Can J Anesth 2015;62:798–806.  Back to cited text no. 13
Lee HJ, Kim KS, Jeong JS, Shim JC, Cho ES. Optimal positive end-expiratory pressure during robot-assisted laparoscopic radical prostatectomy. Korean J Anesthesiol 2013;65:244–51.  Back to cited text no. 14
Kundra P, Yamini S, Ravishankar M, Sistla SC, Nagappa M, Sivashanmugam T. Cardiorespiratory effects of balancing PEEP with intra-abdominal pressure during laparoscopic cholecystectomy. Surg Laparosc Endosc Percutan Tech 2014;24:232-9.  Back to cited text no. 15
Maracajá-neto LF, Verçosa N, Roncally AC, Giannella A, Bozza FA, Lessa MA. Beneficial effects of high positive end-expiratory pressure in lung respiratory mechanics during laparoscopic surgery. Acta Anaesthesiol Scand 2009;53:210–17.  Back to cited text no. 16
Karsten J, Luepschen H, Grossherr M, Bruch HP, Leonhardt S, Gehring H, et al. Effect of PEEP on regional ventilation during laparoscopic surgery monitored by electrical impedance tomography. Acta Anaesthesiol Scand 2011;55:878-86.  Back to cited text no. 17
Arinalp HM, Bakan N, Karaören G, Şahin ÖT, Çeliksoy E. Comparison of the effects of PEEP levels on respiratory mechanics and elimination of volatile anesthetic agents in patients undergoing laparoscopic cholecystectomy; Aprospective, randomized, clinical trial. Turk J Med Sci 2016;46:1071-7.  Back to cited text no. 18
Spadaro S, Karbing DS, Mauri T, Marangoni E, Mojoli F, Valpiani G, et al. Effect of positive end-expiratory pressure on pulmonary shunt and dynamic compliance during abdominal surgery. Br J Anaesth 2016;116:855–61.  Back to cited text no. 19


  [Figure 1], [Figure 2], [Figure 3]

  [Table 1], [Table 2], [Table 3]


Previous article    Next article
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  IN THIS Article
   Materials and Me...
   Article Figures
   Article Tables

 Article Access Statistics
    PDF Downloaded132    
    Comments [Add]    

Recommend this journal