ORIGINAL ARTICLE
Year : 2020  |  Volume : 14  |  Issue : 1  |  Page : 44-47

Comparison of injection pain in pediatric population; original versus generic rocuronium


Department of Anesthesiology, Aichi Children's Health and Medical Center, 426 Nana-Chome, Morioka-Cho, Obu-City, Aichi, Japan

Correspondence Address:
Dr. Hiromi Kako
Department of Anesthesiology, Aichi Children's Health and Medical Center, 426 Nana-Chome, Morioka-Cho, Obu-City - 478-8710, Aichi
Japan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sja.SJA_338_19

Rights and Permissions

Background: Rocuronium-induced injection pain causes withdrawal movements. These movements may cause accidental disruption of indwelling needles. Generic rocuronium contains low-acid concentration buffer solution compared with original rocuronium. In animal experiments, it has been suggested that the difference of the buffer solution may alleviate injection pain. The purpose of this study was to identify the difference of injection pain between original and generic rocuronium in pediatric population. Material and Methods: Patients ranging in age from 1 to 15 years, American Society of Anesthesiologists physical status I or II, undergoing elective surgeries were randomly allocated to two groups; generic rocuronium group (Group R) and original rocuronium (Eslax®) group (Group E). Following anesthetic induction with oxygen, nitrous oxide, and sevoflurane, original or generic rocuronium (1 mg/kg) was administered via intravenous catheter. The difference of vital signs and withdrawal movement associated with rocuronium injection were evaluated. Results: A total of 64 patients were included in the study. Three patients were excluded. Twenty-nine patients were assigned to Group E and 32 patients to Group R. There was no significant difference in mean arterial pressure and heart rate. No withdrawal movements were observed in both groups. Conclusion: There was no significant difference in injection pain between original and generic rocuronium under inhalational induction.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed559    
    Printed21    
    Emailed0    
    PDF Downloaded41    
    Comments [Add]    

Recommend this journal