Year : 2018  |  Volume : 12  |  Issue : 1  |  Page : 61-66

Randomized comparison between dexmedetomidine and midazolam for prevention of emergence agitation after nasal surgeries

1 Department of Anesthesiology, Shri Sathya Sai Medical College and Research Institute, Kancheepuram, India
2 Department of Pain Medicine, Shri Sathya Sai Medical College and Research Institute, Kancheepuram, India
3 Fortis Malar Hospital, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Krishnagopal Vinod
Department of Anesthesiology, Shri Sathya Sai Medical College and Research Institute, Tiruporur-Guduvanchery Main Road, Ammapettai, Kancheepuram, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sja.SJA_419_17

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Background: Emergence agitation (EA) in nasal surgeries is seen in around 22% of patients, which can go to dangerous levels. Dexmedetomidine is effective in prevention of EA in such patients. Midazolam given as premedication fails to prevent EA due to its short half-life. In this study, we compared efficacy of dexmedetomidine and midazolam by intravenous infusion for prevention of EA in adult nasal surgeries. Materials and Methods: Seventy patients belonging to American society of anesthesiologist Status I and II, between 18 and 60 years of age posted for elective nasal surgeries were randomly divided into two groups. Group D received intravenous dexmedetomidine 0.5 mcg/kg over 15 min followed by 0.1 mcg/kg/h. Group M received intravenous midazolam 0.02 mg/kg over 15 min followed by 0.02 mg/kg/h. EA scores, emergence times, and hemodynamic parameters were monitored and compared between the groups. Statistical analysis was done by independent t-test, Mann–Whitney U-test, and Chi-square test as applicable. Results: Incidence of EA was comparable between the groups (P = 0.23). Two patients in midazolam group developed dangerous agitation while none in dexmedetomidine group. Patients in midazolam group (12.4%) were agitated even in postoperative period, which was not seen with dexmedetomidine group. Hypotension and bradycardia were seen more in dexmedetomidine group. Conclusion: Efficacy of midazolam when given as an intravenous infusion is comparable to dexmedetomidine in prevention of EA in nasal surgeries.

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