| ORIGINAL ARTICLE |
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| Year : 2015 | Volume
: 9
| Issue : 3 | Page : 289-292 |
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Repeated dose of ketamine effect to the rat hippocampus tissue
Mehtap Okyay Karaca1, Mustafa Süren2, Zafer Ismail Karaca3, Semih Arici2, Serkan Karaman2, Hüseyin Aslan3, Ziya Kaya2, Serkan Dogru2
1 Department of Anesthesiology and Reanimation, Niksar State Hospital, Tokat, Turkey
2 Department of Anesthesiology and Reanimation, Gaziosmanpasa University, Tokat, Turkey
3 Department of Histology and Embryology, Gaziosmanpasa University, Tokat, Turkey
Correspondence Address:
Dr. Mehtap Okyay Karaca
Department of Anesthesiology and Reanimation, Niksar State Hospital, Tokat
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1658-354X.154726
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Aim: We aimed to determine the neurotoxic effect of repeated ketamine administration on brain tissue and if neurotoxic effect was present, whether this effect continued 16 days later using histological stereological method, a quantitative and objective method. Materials and Methods: Female rats were divided into three groups, each containing five rats. Rats in Group I were given 0.9% saline solution 4 times a day for 5 days. The rats in Groups II and III were given ketamine as intraperitoneal injections. Rats in Groups I and II were sacrificed on 5 th day while the ones in Group III on 21 st day. Cornu ammonis (CA) and gyrus dentatus (GD) regions in hippocampus tissue of rats were studied using optic fractionation method. Findings: There were significantly less number of cells in hippocampal CA and GD regions of rats from Groups II and III compared to the ones from Group I. Difference in cell number was also significantly higher in Group III than in Group II, but this difference was not as pronounced as the one between Groups III and I. Conclusion: Repeated ketamine doses caused neurotoxicity in rat hippocampus. |
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