| CASE REPORT |
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| Year : 2014 | Volume
: 8
| Issue : 3 | Page : 437-439 |
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Vaginal delivery in a patient with pheochromocytoma, medullary thyroid cancer, and primary hyperparathyroidism (multiple endocrine neoplasia type 2A, Sipple's syndrome)
Muhammad Anas Muzannara, Nasser Tawfeeq, Mahmood Nasir, Mohammed Khulaif Al Harbi, Georges Geldhof, Vassilios Dimitriou
Department of Anesthesia, King Abdulaziz Medical City, Riyadh, Saudi Arabia
Correspondence Address:
Prof. Vassilios Dimitriou
Department of Anesthesia, King Abdulaziz Medical City, Riyadh
Saudi Arabia
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1658-354X.136652
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Multiple endocrine neoplasia 2A (MEN 2A), or Sipple's syndrome is a rare inherited dominant syndrome, characterised by medullary thyroid carcinoma, adrenal pheochromocytoma and hyperparathyroidism, due to specific RET proto-oncogene mutations. The women with MEN 2A syndrome are at risk of complicated pregnancy because of unrecognised pheochromocytoma and transmission of RET mutation to the progeny. We report a case of a woman with MEN 2A diagnosed in early pregnancy. Alpha-blockade medical therapy was used effectively and time was given for fetal maturation. Uncomplicated vaginal delivery performed under epidural analgesia. Six weeks postpartum adrenalectomy, thyroidectomy and parathyroidectomy were performed uneventfully. |
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