| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 8
| Issue : 2 | Page : 220-223 |
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The effect of pre-operative administration of gabapentin on post-operative pain relief after herniorrhaphy
Alireza Mahoori1, Heydar Noroozinia1, Ebrahim Hasani1, Sonia Hosainzadeh2
1 Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran
2 Imam Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, Iran
Correspondence Address:
Heydar Noroozinia
Department of Anesthesiology, Imam Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia
Iran
 Source of Support: The authors have no financial interests
related to the material in the manuscript.,Our Research
Project was partially or fully sponsored Urmia University of
Medical Sciences, Urmia, Iran, Conflict of Interest: None  | Check |
DOI: 10.4103/1658-354X.130722
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Background: Gabapentin, an anticonvulsant, recently has been suggested as an effective post-operative "analgesic" agent. The objective of the present study was to examine the analgesic effectiveness and opioid-sparing effects associated with the use of a single dose of gabapentin as a prophylactic analgesic. Materials and Methods: In a randomized double-blinded clinical trial, 50 American Society of Anesthesiologists I and II patients with an age range of 40-60 years who were the candidate for inguinal herniorrhaphy under spinal anesthesia were randomly assigned to receive 400 mg gabapentin or placebo 2 h prior to surgery. Post-operatively, the pain was assessed on a visual analog scale (VAS) at 2, 4, 12 and 24 h at rest. Morphine 0.05 mg/kg intravenously was used to treat post-operative pain on patient's demand. Total morphine consumption in the first 24 h after surgery was also recorded. Results: Patients in the gabapentin group had significantly lower VAS scores at the all-time intervals of study than those in the placebo group (P < 0.05). The total morphine consumption in the first 24 h after surgery was also significantly lower in gabapentin group than in the placebo group (0.9 ± 1.23 vs. 1.8 ± 1.5; P = 0.003). There was no significant difference between the first time of analgesic request among the two groups. Conclusion: In conclusion, prophylactic administration of gabapentin decreases pain scores and analgesic consumption in the first 24 h after repair of inguinal hernia. |
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