REVIEW ARTICLE
Year : 2013  |  Volume : 7  |  Issue : 2  |  Page : 187-190

Early brain injury and subarachnoid hemorrhage: Where are we at present?


1 Department of Anesthesiology and Perioperative Medicine, Health Sciences Center, University of Manitoba, Winnipeg, Canada
2 Department of Anesthesiology and Perioperative Medicine, Fortis Hospital, Gurgaon, India

Correspondence Address:
Tumul Chowdhury
Department of Anesthesia and Perioperative Medicine, HSC, University of Manitoba, Winnipeg
Canada
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1658-354X.114047

Rights and Permissions

The current era has adopted many new innovations in nearly every aspect of management of subarachnoid hemorrhage (SAH); however, the neurological outcome has still not changed significantly. These major therapeutic advances mainly addressed the two most important sequels of the SAH-vasospasm and re-bleed. Thus, there is a possibility of some different pathophysiological mechanism that would be responsible for causing poor outcome in these patients. In this article, we have tried to compile the current role of this different yet potentially treatable pathophysiological mechanism in post-SAH patients. The main pathophysiological mechanism for the development of early brain injury (EBI) is the apoptotic pathways. The macro-mechanism includes increased intracranial pressure, disruption of the blood-brain barrier, and finally global ischemia. Most of the treatment strategies are still in the experimental phase. Although the role of EBI following SAH is now well established, the treatment modalities for human patients are yet to be testified.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1594    
    Printed52    
    Emailed2    
    PDF Downloaded114    
    Comments [Add]    
    Cited by others 1    

Recommend this journal