Year : 2013  |  Volume : 7  |  Issue : 1  |  Page : 29-32

Role of tranexamic acid in reducing postoperative blood loss and transfusion requirement in patients undergoing hip and femoral surgeries

1 Department of Anaesthesiology, Jawaharlal Nehru Medical College, A.M.U. Aligarh, India
2 R.N.T Medical College, Udaipur, Rajasthan, India

Correspondence Address:
Bikramjit Das
Department of Anaesthesiology, Faculty of Medicine, J. N. Medical College, Aligarh Muslim University, Aligarh - 202 002, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1658-354X.109803

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Context: Pharmacological agents are used to reduce postoperative blood loss. Aims: To assess the effects of tranexamic acid on prevention of bleeding and requirement of blood transfusion after major hip and femoral surgeries. Settings and Design: A prospective, randomized, double blinded study was conducted in the tertiary care teaching hospital. Methods: Ninety ASA grade I-II patients undergoing hip fracture surgery were included in this prospective study. Forty-five patients received tranexamic acid (TA) given in a bolus dose of 500 mg 15 min before surgical incision followed by continuous infusion. The remaining, 45 patients were allocated as a control group. Postoperative bleeding (volume of blood in the drain), percentage fall of hemoglobin, transfusions and complications were recorded. Results: Mean volume of blood in the drain was 39.33±10.09 ml (mean±SD) as compared to 91.11±17.61 ml in placebo group showing a P>0.001. Mean percentage fall in Hb at day 0 was 2.99±3.45 in the study group as compared to 7.70±6.05 in the placebo group (P>0.001), and fall at day 2 in the study group was 0.35±0.74, compared to 2.72±2.70 in the placebo group (P<0.001). The number of patients required blood transfusions were lower in the study group than in the placebo group (P=0.01). Conclusions: We conclude that tranexamic acid significantly reduces postoperative blood loss and transfusion requirements during major hip and femoral surgeries.

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