Year : 2007  |  Volume : 1  |  Issue : 1  |  Page : 7

"Effect of single oral dose of Sodium Rabeprazole administered a night before surgery on the intragastric pH and volume in adult patients undergoing elective surgery" a triple blind placebo controlled clinical trial

1 Department of Anesthesiology, King Khalid University Hospital, Al-Riyadh, Saudi Arabia
2 Department of Anesthesiology and Surgical ICU, College of Medicine & King Saud University Hospitals. Al-Riyadh, Saudi Arabia
3 Department of Physiology, College of Medicine & King Saud University Hospitals, Al-Riyadh, Saudi Arabia

Correspondence Address:
Altaf Hussain
Department of Anesthesiology (41), Post Box No. 7805, King Khalid University Hospital, Al-Riyadh 11472
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

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Back Ground: Saliva, duodenogastric refluxate and blood due to gastric mucosal entrapment can affect both pH and volume of gastric contents while sampling from stomach. This issue has never been exposed while evaluating the effectiveness of drugs used for the prophylaxis of acid aspiration. We considered all these factors. Methods: This prospective, triple blind, randomized and placebo controlled clinical trial was conducted to explore the effect of single oral dose of Sodium Rabeprazole 20 mg on intragastric pH and volume in 100 adult inpatients of either sex, ASA I-III, and aged 15-70 years. The patients in Group S received (Sodium Rabeprazole 20 mg) while Group C received Placebo orally at 9.00 p.m., a night before elective surgery. Gastric contents were aspirated with a large bore, multi-orifices gastric tube passed through an endotracheal tube placed blindly in esophagus after tracheal intubation and analyzed for the presence of bile salts, pH and volume. Results: Fifteen cases (15.15%) were contaminated with duodenal contents and one with blood (1%). The proportion of the patients considered" at risk" according to the criteria defined (pH ≤ 2.5 and volume ≥ 25 ml) was statistical significant in Group S compared with Placebo (p value 0.0005). Conclusion: Oral Sodium Rabeprazole 20 mg administered a night before elective surgery does improve the gastric environment at the time of induction of anesthesia, should the aspiration of gastric contents occur.

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