Saudi Journal of Anaesthesia

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 7  |  Issue : 4  |  Page : 373--377

Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries


Sherif S Sultan 
 Department of Anesthesia and Intensive Care, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Sherif S Sultan
24, Muhammad Al-Maqreef St. Nasr City, Cairo
Egypt

Context: Cytokine release is a well-known response to surgery especially when it is linked to cancer. Paravertebral block (PVB) is the suitable regional anesthesia for breast surgery. Aim: We tested the effect of replacing general anesthesia (GA) with PVB on cytokine response during and after surgeries for cancer breast. Settings and Design: Controlled randomized study. Methods: Forty cancer breast patients were divided in two groups; Group I received PVB and Group II received GA during performance of unilateral breast surgery without axillary clearance. Plasma concentrations of interleukin (IL)-6, IL-10, IL-12 and interferon-γ (IFN-γ) were measured and IL-10/IFN-γ were estimated in the following points; before starting PVB in Group I or induction of GA in Group II (Sample A), before skin incision (Sample B), at the end of procedure before shifting out of operating room (Sample C), 4-h post-operatively (Sample D) and 24-h post-operatively (Sample E). Statistical Analysis: unpaired Student t-test. Results: IL-6 increased progressively in both groups with statistically significant lower levels in samples C and D in Group I. IL-10 levels showed progressive increasing in both groups without differences between groups. IL-12 showed progressive decrease in both groups with statistically significant higher levels in samples C and D in Group I. IFN-levels showed significantly higher levels in samples C and D in Group I. IL-10/IFN-γ ratio was significantly lower in Group II in samples C and D. Conclusion: Replacing GA with PVB can attenuate cytokines response to cancer breast surgeries.


How to cite this article:
Sultan SS. Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries.Saudi J Anaesth 2013;7:373-377


How to cite this URL:
Sultan SS. Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries. Saudi J Anaesth [serial online] 2013 [cited 2020 Aug 13 ];7:373-377
Available from: http://www.saudija.org/article.asp?issn=1658-354X;year=2013;volume=7;issue=4;spage=373;epage=377;aulast=Sultan;type=0