Year : 2018  |  Volume : 12  |  Issue : 4  |  Page : 529-534

Enteral nutrition with omega-3 fatty acids in critically ill septic patients: A randomized double-blinded study

Department of Anaesthesia and Intensive Care, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt

Correspondence Address:
Dr. Ezzeldin Saleh Ibrahim
Department of Anaesthesia and Intensive Care, Faculty of Medicine, Menoufia University, Shebeen El-Kom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sja.SJA_50_18

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Purpose: The present study was done to investigate the effect of the enteral omega-3 fatty acids on critically ill septic patients. Methods: A total of 110 critically ill septic patients were divided into two groups, 55 patients in each. Group A received enteral nutrition with 1000 mg omega-3 three times daily and Group B received enteral nutrition without omega-3. Demographic data, sepsis characteristics, number of patients required invasive ventilation, ventilation days, Intensive Care Unit (ICU) sequential organ failure assessment (SOFA) score, organ failure-free days, hemodynamic failure-free days, ICU stay, ICU, and hospital outcome were recorded. Results: Leukocytic count and C-reactive protein were higher in Group B during ICU stay (P = 0.010 and 0.003, respectively). The number of organ and hemodynamic failure-free days was higher in Group A (P < 0.05). Overall, ICU SOFA score was higher in Group B (P = 0.03). There was no difference in the number of patients requiring mechanical ventilation (P = 0.41). ICU stay was longer in Group B (P = 0.019); however, post-ICU hospital stay was similar in both groups. There were no differences regarding ICU and hospital survivors (P > 0.05). Conclusions: Enteral nutrition with omega-3 can improve organ function and decrease ICU stay in septic patients. Omega-3 fatty acids do not affect ICU mortality or decrease the post-ICU hospital stay.

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