REVIEW ARTICLE
Year : 2015  |  Volume : 9  |  Issue : 4  |  Page : 451-456

Etomidate in pediatric anesthesiology: Where are we now?


Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital; Departments of Anesthesiology and Pain Medicine; Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

Correspondence Address:
Joseph D Tobias
Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, 700 Children's Drive Columbus, Columbus, Ohio
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1658-354X.159475

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Etomidate is an intravenous anesthetic agent released for clinical use in the United States in 1972. Its popularity in clinical practice is the result of its beneficial effects on intracerebral dynamics with limited effects on hemodynamic function. These properties have made it a safe and effective anesthetic induction agent in both adult and pediatric patients with altered myocardial performance, congenial heart disease, or hypovolemia. However, recent concern has been expressed regarding its effects on the endogenous production of corticosteroids and the impact of that effect on patient outcomes. The following manuscript reviews clinical reports regarding etomidate use in the pediatric population and discusses recent concerns regarding its effects on corticosteroid metabolism and the implications of such effects for clinical use.


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