Year : 2015 | Volume
| Issue : 4 | Page : 381-385
ED50 of sevoflurane for I-Gel removal in anesthetized children in cataract surgeries using subtenon block
Sameer Sethi1, Babita Ghai1, Dipika Bansal2, Jagat Ram3
1 Department of Anesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
2 Department of Pharmacy, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, India
3 Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India
Department of Anesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh - 160 012
Source of Support: None, Conflict of Interest: None
Clinical trial registration CTRI/2014/03/004507
|Date of Web Publication||16-Sep-2015|
Objective: The aim of this study was to determine the minimum concentration of sevoflurane required for I-Gel removal in 50% children undergoing elective cataract surgery. Design: A prospective observational study. Setting: A single tertiary care surgical center. Materials and Methods: Our study enrolled 20 American Society of Anesthesiologists I and II children aged 2-10 years, undergoing elective cataract surgery. Anesthesia was induced with sevoflurane and oxygen/nitrous oxide mixture and a size 2 I-Gel was inserted. A subtenon block was administered in all children before surgical incision. Sevoflurane was used for maintenance of anesthesia. Predetermined end-tidal concentration of sevoflurane was maintained for 10 min at the end of surgery before I-Gel removal was attempted. End-tidal concentrations were increased/decreased using the Dixon up-down method (with 0.2% as a step size) in the next patient depending on the previous patient's response. Patient responses to I-Gel removal were classified as "movement" or "no movement". Results: Minimum concentration of sevoflurane required for successful removal of a I-Gel in 50% (ED50) and 95% (ED95) of children was 0.44% (95% confidence interval [CI], 0.34-0.52%) and 0.77% (95% CI, 0.63-1.2%), respectively. Conclusion: A very low end-tidal concentration of sevoflurane (ED50 of 0.44% ED95 of 0.77%) is required for I-Gel removal in children in cataract surgery with the supplementation of subtenon block.
Keywords: Cataract surgeries, I-Gel removal, pediatric, sevoflurane, subtenon block
|How to cite this article:|
Sethi S, Ghai B, Bansal D, Ram J. ED50 of sevoflurane for I-Gel removal in anesthetized children in cataract surgeries using subtenon block. Saudi J Anaesth 2015;9:381-5
|How to cite this URL:|
Sethi S, Ghai B, Bansal D, Ram J. ED50 of sevoflurane for I-Gel removal in anesthetized children in cataract surgeries using subtenon block. Saudi J Anaesth [serial online] 2015 [cited 2019 Jun 24];9:381-5. Available from: http://www.saudija.org/text.asp?2015/9/4/381/159460
| Introduction|| |
I-Gel is one of the newer second generation noninflatable supraglottic airway devices, which is made up of a transparent, soft, gel-like elastomer  which results in higher seal pressures with negligible tissue compression when compared with other inflatable supraglottic airway devices. ,
Several studies have compared the performance of pediatric version of I-Gel™ (Intersurgical Ltd., Wokingham, and Berkshire, UK) with classic laryngeal mask airway (CLMA) and found comparable results with respect to ease of insertion, hemodynamic variables, and postoperative complications. ,,,
However, the minimum alveolar concentration (MAC) of sevoflurane required for CLMA removal for 50% of unpremeditated children (ED50) is reported to be in the range of around 2.0%.(1.84-1.90%). , We hypothesize that ED50 of sevoflurane to be in the same range with that of CLMA. The MAC of sevoflurane for 50% (ED50) and 95% (ED95%) successful removal of I-Gel in children has not been studied to date and therefore, we planned this study to determine the sevoflurane ED50 and ED95 for I-Gel removal in children undergoing cataract surgeries with the supplementation of subtenon block.
| Materials and Methods|| |
This was a single center, prospective, observational study to determine the dose-response curve, as well as ED50 and ED95 of sevoflurane for removal of I-Gel in pediatric subjects. Study was done in accordance to the Consolidated Standards of Reporting Trials guidelines (CONSORT 2010 Checklist) and following the principles of the Declaration of Helsinki and was registered with the Clinical Trial Registry of India (CTRI) with an assigned number of CTRI/2014/03/004507.
The study proceeded after obtaining approval of Institute Ethics Committee of Post Graduate Institute of Medical Education and Research, Chandigarh, India (NK/1252/Department/4131). Written informed parental consent was obtained before enrolment of each child. Paediatric subjects of either sex aged 1.5-8 years, weighing 10-20 kg having American Society of Anesthesiologists physical status I/II of undergoing elective cataract surgery were recruited in the study. Children with recent upper respiratory tract infection, increased risk for aspiration, airway anomalies, and cardiorespiratory or cerebrovascular disease were excluded from the study.
Premedication was not administered to any child. Induction and maintenance of anesthesia were achieved with sevoflurane and oxygen with preservation of spontaneous breathing. After establishing intravenous access, size 2 I-Gel was inserted for maintenance of airway after achieving sufficient depth of anesthesia. Anesthesia was maintained with 2-3% sevoflurane in oxygen and nitrous oxide. A subtenon block with 0.08-0.10 ml/kg of 0.5% bupivacaine was administered in all children 8-10 min before surgical incision. 0.5 μg/kg of an intravenous fentanyl bolus was administered, whenever the heart rate or mean arterial pressure increased >20%. Heart rate, noninvasive blood pressure, electrocardiogram, SpO 2 , end-tidal sevoflurane (ET SEVO ), MAC, and ET CO 2 were monitored intraoperatively.
After the end of surgery, nitrous oxide was switched off, and the target ET SEVO was maintained for 8-10 min before I-Gel removal was attempted. The sevoflurane end-tidal concentration of was kept at 2% in first child. ET SEVO was increased or decreased by 0.2% in the next child depending on the previous child's response according to Dixon's method.  After each I-Gel removal, child was observed for 1 min for any "Movement" or "No Movement." It was designated as "movement" or unsuccessful removal of I-Gel in case of purposeful movement of extremities, difficult mouth opening, clenching of teeth, coughing, breath holding, laryngospasm, and desaturation during or within 1 min of SAD insertion. An independent observer assessed these responses. Any adverse events were recorded.
Data were represented as mean and standard deviation or number with percentages. Chi-square test and t-test were applied for categorical variables and continuous variables, respectively. Sevoflurane ED50 was calculated using Dixon up and down method.
Further analyzing with a probit regression, dose-response curve was obtained with ED50 and ED95 with 95% confidence interval (CI). Sample size was calculated on the basis of fact that a minimum of six crossover pairs were required for the statistical analysis.  Data analysis was done using SPSS version 17.0. (Contractor/manufacturer is SPSS Inc., 233 South Wacker Drive, 11th Floor, Chicago, IL 60606-6412)
| Results|| |
Totally, 22 children were assessed for study eligibility of which parents of 2 children refused to participate, therefore the total of 20 children met the inclusion criteria and were included in the study [Figure 1].
Demographic data in the form of patient and anesthesia characteristics such as age, gender, weight, duration of anesthesia, and duration of surgery are shown in [Table 1]. ED50 and ED95 of sevoflurane for I-Gel removal using probit regression analysis were 0.44% (95% CI, 0.34-0.52%) and 0.77% (95% CI, 0.63-1.2%), respectively [Figure 2] and [Table 2].
The sequence of successful and unsuccessful removal of I-Gel is shown in [Figure 3]. I-Gel was successfully removed in 13 (65%) out of 20 children.
|Figure 3: Dose-response curve for sevoflurane plotted from the probit analyses of individual end-tidal concentrations and the respective patient reactions to the removal of I-Gel. The concentrations at which there were 50% probabilities of successful I-Gel removal were 0.44%|
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Movement occurred in 4 patients (at 0.25% each). No other complication such as coughing, clenching, laryngospasm, breath holding, or desaturation occurred in any of the children.
| Discussion|| |
Our results showed ED50 and ED 95 of sevoflurane for I-Gel removal in children undergoing cataract surgery supplemented with subtenon block to be 0.44% and 0.77% and none of the children had any of the major airway related events.
This is the first study in literature to determine the minimum concentration of sevoflurane (ED50 and ED95) for I-Gel removal in children.
Studies have shown the ED50 of sevoflurane for removal of other supraglottic devices like CLMA to be around 2%. , Thus, we found ED50 of sevoflurane for I-Gel removal to be even less than one-fourth of the ED50 of sevoflurane required for CLMA removal and is better tolerated than other supraglottic devices such as LMA. It is because of this low EC that there are negligible airway-related events following removal of the device in our study. These results are probably because of the soft consistency of mask of the device without an inflatable cuff ,,,, facilitating smooth removal of the device with negligible tissue trauma and reducing the chances of airway complications due to airway stimulation by the device resulting in lesser chances of failure at removal with lesser hemodynamic changes  which may lead to improved recovery time and fewer postoperative complications.  In our study, there were no significant airway complications apart from movement which suggested smooth removal of I-Gel in these children.
Such a lower end-tidal sevoflurane concentration for I-Gel removal can also be beneficial in penetrating eye injuries or in glaucomatous patients in preventing any rise in intraocular pressure and also preventing suture dehiscence. ,
One of the limitations of the study is the use of Dixon's method with probit regression analysis for calculation of ED95, but this method has been used in many studies by researchers. ,
Due to non-availability of medical air we used nitrous oxide which could lead to inaccurate measurement but ensured that no end-tidal nitrous oxide was present at the time of removal of I-Gel and thus minimized the any chances of error.
Another limitation is the absence of the control group without subtenon block. We used subtenon block as we have omitted the use of opioids which could have a confounding systemic effect on the end-tidal concentration of sevoflurane.
| Conclusion|| |
It can be concluded that a very low end-tidal concentration of sevoflurane (ED50 of 0.44% ED95 of 0.77%) is required for I-Gel removal in children in cataract surgery with the supplementation of subtenon block.
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[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2]