Year : 2014 | Volume
| Issue : 2 | Page : 233-237
Pain relief after Arthroscopic Knee Surgery: A comparison of intra-articular ropivacaine, fentanyl, and dexmedetomidine: A prospective, double-blinded, randomized controlled study
Mohammed Babrak Manuar1, Saikat Majumdar1, Anjan Das2, Bimal Kumar Hajra1, Soumyadip Dutta3, Dipankar Mukherjee1, Tapobrata Mitra4, Ratul Kundu4
1 Department of Anaesthesiology, NRS Medical College, Kolkata, West Bengal, India
2 Department of College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India
3 Department of Orthopedics, R.G. Kar Medical College, Kolkata, West Bengal, India
4 Department of R.M.O cum CT, B.I.N, Kolkata, West Bengal, India
174, Gorakshabashi Road, Royal Plaza Apartment (4th Floor, Flat No-1), Nagerbazar, Kolkata - 28, West Bengal
Source of Support: None, Conflict of Interest: None
|Date of Web Publication||16-Apr-2014|
Background: Postoperative pain is very common distressing symptom after any surgical procedure. Different drugs in different routes have been used for controlling post-arthroscopic pain. No one proved to be ideal. We have compared the analgesic effect of ropivacaine, fentanyl, and dexmedetomidine when administered through the intra-articular route in arthroscopic knee surgery. Materials and Methods: From March 2008 to July 2010, 99 patients undergoing arthroscopic knee surgery were randomly assigned into three groups (A,B,C) in a prospective double-blinded fashion. Group A received 10 ml of 0.75% ropivacaine, where Group B received 50 μg fentanyl, and Group C received 100 μg of dexmedetomidine through the intra-articular route at the end of procedure. Pain assessed using visual analog scale and diclofenac sodium given as rescue analgesia when VAS >4. Time of first analgesia request and total rescue analgesic used in 24 hours were calculated. Results: Demographic profiles are quite comparable among the groups. Time for requirement of first postoperative rescue analgesia in Group A was 380.61 ± 22.973 min, in Group B was 326.82 ± 17.131 min and in Group C was 244.09 ± 20.096 minutes. Total rescue analgesia requirement was less in Group A (1.394 ± 0.496) compared to Group B (1.758 ± 0.435) and Group C (2.546 ± 0.546). Group A had higher mean VAS score at 6 th and 24 th postoperative hours. No side effects found among the groups. Conclusion: Therefore, it suggests that intra-articular ropivacaine gives better postoperative pain relief, with increased time of first analgesic request and decreased need of total postoperative analgesia compared to fentanyl and dexmedetomidine.
Keywords: Dexmedetomidine, fentanyl, intra-articular, rescue analgesia, ropivacaine
|How to cite this article:|
Manuar MB, Majumdar S, Das A, Hajra BK, Dutta S, Mukherjee D, Mitra T, Kundu R. Pain relief after Arthroscopic Knee Surgery: A comparison of intra-articular ropivacaine, fentanyl, and dexmedetomidine: A prospective, double-blinded, randomized controlled study. Saudi J Anaesth 2014;8:233-7
|How to cite this URL:|
Manuar MB, Majumdar S, Das A, Hajra BK, Dutta S, Mukherjee D, Mitra T, Kundu R. Pain relief after Arthroscopic Knee Surgery: A comparison of intra-articular ropivacaine, fentanyl, and dexmedetomidine: A prospective, double-blinded, randomized controlled study. Saudi J Anaesth [serial online] 2014 [cited 2020 Sep 22];8:233-7. Available from: http://www.saudija.org/text.asp?2014/8/2/233/130727
| Introduction|| |
Postoperative arthroscopic knee surgery is the one of the most common minimally invasive surgical procedures in modern orthopedic setup. It is associated with variable amount of postoperative pain, which is caused by irritation of free nerve endings of synovial tissue, anterior fat pad, and joint capsule during surgical excision and resection.  Undoubtedly, postoperative pain has a negative impact on patient's early mobilization, rehabilitation, and psychology. This leads to prolonged hospital stay. Adequate pain relief reduces surgical stress response, so reduces patient's morbidity and improves postoperative recovery. Several analgesic strategies such as systemic medication (narcotic, NSAID),  central or peripheral nerve block, and intra-articular drug administration (ketorolac,  α2 -agonists, ,,, opioids, ,,,, local anesthetics ,,, ) have been used to interrupt the pain pathway, which is called a multimodal approach. However, none is free from limitations such as needs for special equipments, monitoring, and risks of complications. Utilizing the peripheral receptors for postoperative pain management is an important mode of such an approach. The intra-articular route of drug administration is an example for management of pain after joint surgery utilizing the peripheral receptors. It provides analgesia locally with minimal systemic side effects.
Different authors in their previous studies with intra-articular ropivacaine,  fentanyl,  and dexmedetomidine  had proved their efficacy in providing postoperative analgesia in arthroscopic knee surgery. Ropivacaine is an amino-amide local anesthetic that blocks the peripheral afferents acting on voltage-dependent Na + channels. It is less toxic than other long-acting local anesthetics like bupivacaine. Fentanyl is a synthetic opioid most commonly used for analgesia in clinical anesthesia practice. Opioids can also elicit an analgesic effect by acting on peripheral opioid receptors. , Dexmedetomidine is highly selective (eight time more selective than clonidine),  specific, and potent; α2 -adrenergic agonist has analgesic, sedative, antihypertensive, and anesthetic sparing effects when used in a systemic route.  Our study was carried out to compare the analgesic efficacy of ropivacaine, fentanyl, and dexmedetomidine in the intra-articular route following arthroscopic knee surgery.
| Materials and Methods|| |
The study was approved by the Institutional Ethical Committee. ASA physical status I and II, aged between 18 and 60 years of both sexes undergoing elective arthroscopic knee surgery (like synovectomy, ligament reconstruction, and articular cartilage procedures) under spinal anesthesia are included in this study. Selected patients (N = 99) are randomly allocated in three groups (33 patients in each groups). Patients in Group A received 10 ml of 0.75% ropivacaine. Group B received 50 mcg of fentanyl diluted in 10 ml normal saline. Group C received 100 mcg of dexmedetomidine diluted in 10 ml of normal saline. Total volume of drug was 10 ml in each group.
Exclusion criteria: Patient refusal, any known allergy or contraindication to ropivacaine, fentanyl or dexmedetomidine, pregnancy, lactating mothers and children, hepatic, renal or cardiopulmonary abnormality, alcoholism, diabetes, long-term analgesic therapy, spinal cord deformities, bleeding diathesis, local skin site infections are excluded from the study.
In the preoperative assessment, the patients were enquired about any history of drug allergy, previous operations, or prolonged drug treatment. General examination, systemic examinations, and assessment of the airway were done. Preoperative fasting of minimum 6 hours was ensured before operation in all day care cases. All patients received premedication of tablet diazepam 10 mg orally the night before surgery as per preanesthetic check up direction to allay anxiety, apprehension, and for sound sleep. The patients also received tablet ranitidine 150 mg with sips of water in the previous night and in the morning of operation.
All patients were clinically examined in the preoperative period, when whole procedure was explained and written consent obtained. A 10 cm visual analog scale (VAS) (0, no pain and 10, worst pain imaginable) was also explained during preoperative visit. All patients were investigated for Hb%, TLC, DLC, ESR, platelet count, blood sugar, blood urea, serum creatinine, and liver function tests. A 12-lead ECG and chest X-ray were also taken. On entering the patient in the operative room, standard intraoperative monitors like ECG, pulse oxymeter, non-invasive blood pressure were attached and baseline parameters were recorded. Philips IntelliVue MP20 monitor was used for this purpose.
The anesthetic technique was standardized for all patients. Lumber puncture was done in sitting position at L3 and L4 inter-vertebral space in median approach with 25-Gauge spinal needle. Then maintaining sitting position, 3 ml of 0.5% hyperbaric Bupivacaine was given in subarachnoid space and the patient was placed in the supine position immediately. After 5 minutes of subarachnoid injection, arthroscopic procedure is allowed to start confirming level of block. During the procedure if any patient needed further dose of analgesia, that patient was excluded from the study. At the end of surgery before skin closure, the study drug was administered by the surgeon through the port site in the intra-articular space. Tourniquet was kept inflated for another 20 minutes. Drain put by the surgeon was clamped before administering the study drug and remained clamped for another 20 minutes. HR, NIBP, RR, SPO 2 , ECG, and pain VAS will be recorded at 1 st , 2 nd , 4 th , 6 th , 12 th , and 24 th postoperative hours. Injection diclofenac sodium (75 mg IM) was given as rescue analgesia if the pain VAS >4. First postoperative analgesia request time, total diclofenac used in first 24 hours were recorded. All data will be collected by an observer who is unaware of patients' group assignment.
Statistical analysis: Sample size was estimated using time of first analgesic request as the main primary variable. On the basis of previous study, assuming within group SD of 40 minutes and the true difference in mean time to requirement of first dose rescue analgesic to be 30 minutes, we needed to study 33 experimental subjects per group to be able to reject the null hypothesis that the population means of the groups are equal with probability (power) 0.85. Raw data were entered into a MS Excel spreadsheet and analyzed using standard statistical software SPSS ® statistical package version 18.0 (SPSS Inc., Chicago, IL, USA). Categorical variables were analyzed using the Pearson's chi square test. Normally distributed continuous variables were analyzed using the one-way ANOVA followed by the Boneferroni test and P < 0.05 was considered statistically significant.
| Results|| |
There were no significant differences between the three groups with regard to demographic data such as age, sex, weight, height, and duration of surgery [Table 1] and [Table 2]. A majority of the patient had undergone repair of the anterior cruciate ligament. Time for the request of first postoperative rescue analgesia in Group A [380.61 ± 22.973 minutes] was longer compared to Group B [326.82 ± 17.131 minutes] and Group C [244.09 ± 20.096 minutes] (P < 0.05) [Table 3] and [Figure 1]. The total number of rescue analgesia requirement in first 24 hours in postoperative period was also less in Group A [1.394 ± 0.496] compared to Group B [1.758 ± 0.435] and Group C [2.546 ± 0.506)] (P > 0.05) [Table 4] and [Figure 2]. The VAS score was 0 in all the groups at first postoperative hour. Compared with Group B and Group C, Group A had higher mean VAS score at 6 th and 24 th postoperative hours [Figure 3]. No incidence of adverse effects like nausea, vomiting, urinary retention, itching, or sedation was observed in any one in the study population.
|Figure 1: Showing time of 1st postoperative analgesia request in Group A (Ropivacaine), Group B (Fentanyl) and Group C (Dexmedetomidine).|
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|Figure 2: Showing total number of rescue analgesia in 1st post operative 24 hours in Group A (Ropivacaine), Group B (Fentanyl) and Group C (Dexmedetomidine).|
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|Figure 3: Showing the comparison of VAS score at 1st, 2nd, 4th, 6th, 12th and 24th post operative hours in Group A (Ropivacaine), Group B (Fentanyl) and Group C (Dexmedetomidine).|
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|Table 2: Comparison of demographic sex distribution among the study groups|
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|Table 3: Showing mean, standard deviation, and signifi cance level of duration of postoperative analgesia in minutes|
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|Table 4: Showing mean, standard deviation, and signifi cance of total no of rescue analgesia in first post operative 24 hours|
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| Discussion|| |
Arthroscopic surgery is associated with variable amount of postoperative pain. The intra-articular route of drug administration has an important role to provide postoperative analgesia after the arthroscopic procedure. Different authors in their study have proved the analgesic efficacy of intra-articular ropivacaine, fentanyl, and dexmedetomidine after an arthroscopic procedure. Better time of postoperative analgesia and decreased requirement of rescue analgesia in intra-articular drug administration may be due to slower rate of absorption through poorly vascular intra-articular surface. In our prospective double-blinded randomized comparative study, we have compared the analgesic efficacy of intra-articular ropivacaine, fentanyl, and dexmedetomidine following arthroscopic knee surgery.
Ropivacaine is a commonly used local anesthetic and it is related structurally to bupivacaine. It is less lipid soluble than bupivacaine, but its pharmacokinetic deposition is similar. Ropivacaine seemed to provide similar and effective post-arthroscopy analgesia compared to bupivacaine, showing less CNS and cardiac toxicity.  Samoladas et al. (2006) found that intra-articular ropivacaine is effective to reduce postoperative pain minimizing the use of systemic analgesia.  This study also stated that intra-articular injection of local anesthetic seems to provide an alternative and effective solution in pain control after knee arthroscopy.
Fentanyl is a synthetic opioid commonly used now a days by anesthetics through systemic for analgesia. The understanding that opioids can elicit analgesic effects by acting on peripheral opioid receptors has led to their experimentation in controlled clinical trials. , The most favorable results have emerged from studies of intra-articular administration of small systemically inactive doses of narcotic during arthroscopic knee surgery. Mondal et al. (2002) reported that intra-articular fentanyl provides prolonged postoperative analgesia following arthroscopic knee surgery.  They found that 50 μ fentanyl provides mean of 23.54 hours postoperative analgesia. But in that study, a majority of procedure was diagnostic arthroscopy.
The analgesic effects of α2 -adenergic agonist could be mediated through supraspinal, spinal, and peripheral action.  In our study, the analgesic effect of intra-articular dexmedetomidine appears mainly due to a direct local action. However, a central analgesic effect resulting from systemic absorption cannot be excluded. The mechanism by which dexmedetomidine mediates intra-articular analgesia is not clearly defined. However, the mechanism of analgesic effects for intra-articular dexmedetomidine might be similar to those suggested for intra-articular clonidine. Clonidine may act on presynaptic α2 -adrenergic receptors and inhibit the release of norepinephrine at peripheral afferent nociceptors.  Clonidine has also been shown to provide a local anesthetic effect which inhibits the conduction of nerve signals through C and Ad fibers  and may stimulate the release of enkephalin-like substances at peripheral sites.  Al-Metwalli et al. (2008) found that intra-articular dexmedetomidine enhanced postoperative analgesia after arthroscopic knee surgery, with an increased time to first analgesic request and a decrease need for postoperative analgesia.  Here intra-articular dexmedetomidine provides mean postoperative analgesia for 6 hours in arthroscopic partial meniscectomy.
Demographic profile parameters mainly age, sex, weight, height and duration of surgery are comparable among the groups. Time for requirement of first postoperative rescue analgesia in Group A was380.61 ± 22.973 min, in Group B was326.82 ± 17.131 min, and in Group C was 244.09 ± 20.096 min [Table 3] and [Figure 1]. Total rescue analgesia requirement was less in Group A [1.394 ± 0.496] compared to Group B [1.758 ± 0.435] and Group C [2.546 ± 0.546] [Table 4] and [Figure 2]. Group A had higher mean VAS score at 6 th and 24 th postoperative hours [Figure 3]. No side effects were found among the groups.
It was clearly found that analgesic efficacy of intra-articular ropivacaine is superior to fentanyl and dexmedetomidine. Intra-articular fentanyl showed moderate efficacy and intra-articular dexmedetomidine showed least efficacy in comparison to other. Further clinical studies can be performed to develop a more reliable and clinically efficient regime. This is so that this regime may be used as a component of a multimodal approach of postoperative analgesia. Further studies are also required to define the optimal analgesic dose of intra-articular ropivacaine after an arthroscopic procedure. A limitation of our study is that we did not follow up the patients whether any local tissue damage occurred or not in intra-articular space due to study drugs.
| Conclussion|| |
Intra-articular ropivacaine increases the duration of analgesia and decreases need of rescue analgesic in first postoperative 24 hours. So intra-articular ropivacaine shows superior analgesic efficacy when compared with intra-articular fentanyl and dexmedetomidine following arthroscopic knee surgery.
| References|| |
|1.||Dye SF, Vaupel GL, Dye CC. Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia. Am J Sports Med 1998;26:773-7. |
|2.||Gurkan Y, Kilickan L, Buluc L, Muezzinoglu S, Toker K. Effect of diclofenac and intra-articular morphine/bupivacaine on postarthroscopic pain control. Minerva Anestesiol 1999;65:741-55. |
|3.||Gupta A, Axelsson K, Allvin R, Liszka-Hackzell J, Rawal N, Althoff B, et al. Postoperative pain following knee arthroscopy: The effect of intra-articular keterolac and/or morphine . Reg Anesth Pain Med 1999;24:225-30. |
|4.||Gentili M, Houssel P, Osman M, Henel D, Juhel A, Bonnet F. Intra-articular morphine and clonidine produce comparable analgesia but the combination is not more effective. Br J Anaesth 1997;79:660-1. |
|5.||Buerkle H, Huge V, Wolfgart M, Steinbeck J, Mertes N, Van Aken H, et al. Intra-articular clonidine analgesia after knee arthroscopy. Eur J Anaesthesiol 2000;17:295-9. |
|6.||Reuben SS, Connelly NR. Postoperative analgesia for outpatient arthroscopic knee surgery with intraarticular clonidine. Anesth Analg 1999;88:729-33. |
|7.||Tan PH, Buerkle H, Cheng JT, Shih HC, Chou WY, Yang LC. Double-blind parallel comparison of multiple doses of apraclonidine, clonidine, and placebo administered intra-articularly to patients undergoing arthroscopic knee surgery. Clin J Pain 2004;20:256-60. |
|8.||Likar R, Kapral S, Steinkellner H, Stein C, Schafer M. Dose-dependency of intra-articular morphine analgesia. British J Anaesth 1999;83:241-4. |
|9.||Varkel V, Volpin G, Ben-David B, Said R, Grimberg B, Simon K, et al. Intra-articular fentanyl compared with morphine for pain relief following arthroscopic knee surgery. Can J Anaesth 1999;46:867-71. |
|10.||Pooni JS, Hickmott K, Mercer D, Myles P, Khan Z. Comparison of intra-articular fentanyl and intra-articular bupivacaine for postoperative pain relief after knee arthroscopy. Eur J Anaesthesiol 1999;16:708-11. |
|11.||Rosseland LA, Stubhaug A, Skoglug A, Skoglund A, Breivik H. Intraarticular morphine for pain relief after knee arthroscopy. Acta Anaesthesiol Scand 1999;43:252-7. |
|12.||Soderlund A, Westman L, Ersmark H, Eriksson E, Valentin A, Ekblom A. Analgesia following arthroscopy- a comparison of intra-articular morphine, pethidine and fentanyl. Acta Anaesthesiol Scand 1997;41:6-11. |
|13.||Allen GC, St Amand MA, Lui AC, Johnson DH, Lindsay MP. Postarthroscopy analgesia with intra-articular bupivacaine/morphine. A randomized clinical trial. Anesthesiology 1993;79:475-80. |
|14.||Chirwa SS, MacLeod BA, Day B. Intra-articular bupivacaine (Marcaine) after arthroscopic meniscectomy: A randomized double-blind controlled study. Arthroscopy 1989;5:33-5. |
|15.||Geutens G, Hambridge JE. Analgesic effects of intra-articular bupivacaine after day-case arthroscopy. Arthroscopy 1994;10:299-300. |
|16.||Moiniche S, Mikkelsen S, Wetterslev J, Dahl JB. A systematic review of intra-articular local anesthesia for postoperative pain relief after arthroscopic knee surgery. Reg Anesth Pain Med 1999;24:430-7. |
|17.||Samoladas EP, Chalidis B, Fotiadis H, Terzidis I, Ntobas T, Koimtzis M. Intra-articular use of ropivacaine for the control of post knee arthroscopy pain. J Orthop Surg Res 2006;1:17. |
|18.||Mondal P, Saudagar AH. Intra-articular Fentanyl for analgesia following arthroscopic knee surgery. Indian J Anaesth 2002;46:107-10. |
|19.||Al-Metwalli RR, Mowafi HA, Ismail SA, Siddiqui AK, Al-Ghamdi AM, Shafi MA, et al. Effect of intra-articular dexmedetomidine on post operative analgesia after arthroscopic knee surgery. Br J Anaesth 2008;101:395-9. |
|20.||Kalso E, Tramèr MR, Carroll D, McQuay HJ, Moore RA. Pain relief from intra-articular morphine after knee surgery; A qualitative systemic review. Pain 1997;71:127-34. |
|21.||Stein C, Schafer M, Cabot PJ, Carter L, Zhang Q, Zhou L, et al. Peripheral opioid analgesia. Pain Rev 1997;4:173-87. |
|22.||Gerlach AT, Dasta JF. Dexmedetomidine: An updated review. Ann Pharmacother 2007;41:245-52. |
|23.||Huang R, Hertz L. Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C] glutamate in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects. Brain Res 2000;873:297-301. |
|24.||Scott DB, Lee A, Fagan D, Bowler GM, Bloomfield P, Lundh R. Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 1989;69:563-9. |
|25.||Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effect of increasing plasma concentration of dexmedetomidine in human. Anesthesiology 2000;93:382-94. |
|26.||Gentili M, Juhel A, Bonnet F. Peripheral analgesic effect of intra-articular clonidine. Pain 1996;64:593-6. |
|27.||Butterworth JF, Strichartz GR. The alpha 2-adrenargic agonists clonidine and gunafacine produce tonic and phasic block of conduction in rat sciatic nerve fibres. Anesth Analg 1993;76:295-30. |
|28.||Nakamura M, Ferreira SH. Peripheral analgesic action of clonidine: Mediation by release of endogenous enkephalin-like substances. Eur J Pharmacol 1988;146:223-8. |
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3], [Table 4]
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