Year : 2012  |  Volume : 6  |  Issue : 2  |  Page : 181-185

Anesthetic considerations in Leigh disease: Case report and literature review

1 Department of Anesthesiology, King Fahad Medical City, Riyadh, Saudi Arabia
2 Department of Anesthesiology, Nationwide Children's Hospital, Columbus, Ohio, USA

Correspondence Address:
Abdullah Sulieman Terkawi
Department of Anesthesiology, King Fahad Medical City, Riyadh
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1658-354X.97037

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Leigh disease is an extremely rare disorder, characterized by a progressive neurodegenerative course, with subacute necrotizing encephalomyelopathy. It usually presents in infancy with developmental delay, seizures, dysarthria, and ataxia. These patients may also develop episodes of lactic acidosis that usually lead to respiratory failure and death. Due to the rarity of the condition, the most appropriate anesthetic plan remains unclear. We present a patient with Leigh disease, who required general anesthesia. The pathogenesis of the disease is discussed and previous reports of perioperative care from the literature are reviewed.

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