REVIEW ARTICLE
Year : 2011  |  Volume : 5  |  Issue : 3  |  Page : 308-313

Negative pressure pulmonary edema revisited: Pathophysiology and review of management


Critical Care Research Group, John B McCarthy Adult Intensive Care Service, The Prince Charles Hospital, Brisbane, Australia

Correspondence Address:
Balu Bhaskar
Intensive Care Specialist, Critical Care Research Group John B McCarthy Adult Intensive Care Service, The Prince Charles Hospital Rode Road, Chermside Brisbane, Queensland 4032
Australia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1658-354X.84108

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Negative pressure pulmonary edema (NPPE) is a dangerous and potentially fatal condition with a multifactorial pathogenesis. Frequently, NPPE is a manifestation of upper airway obstruction, the large negative intrathoracic pressure generated by forced inspiration against an obstructed airway is thought to be the principal mechanism involved. This negative pressure leads to an increase in pulmonary vascular volume and pulmonary capillary transmural pressure, creating a risk of disruption of the alveolar-capillary membrane. The early detection of the signs of this syndrome is vital to the treatment and to patient outcome. The purpose of this review is to highlight the available literature on NPPE, while probing the pathophysiological mechanisms relevant in both the development of this condition and that involved in its resolution.


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