Fentanyl versus dexmedetomidine effect on agitation after sevoflurane anaesthesia
Essam M Manaa1, Ashraf A Abdelhaleem2, Elsayed A Mohamed3
1 Assistant Professor, Anesthesia Department, Assiut University Hospital, Assiut, Egypt; Consultant Anesthetist, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
2 Lecturer of Anesthesia, Alexandria University Hospital, Alexandria University, Egypt; Acting Senior Registrar, Anesthesia Dept., King Abdulaziz University Hospital, Riyadh, Saudi Arabia.
3 Lecturer of Anesthesia, Liver Institute, Menoufiya University, Egypt; Acting Senior Registrar, Anesthesia Dept.,King Abdulaziz University Hospital, Riyadh, Saudi Arabia.
Essam M Manaa
Assistant Professor, Anaesthesia Department, Assiut University Hospital, Assiut, Egypt. Consultant Anaesthetist, King Saud University, King Khalid University Hospital, Riyadh, Saudi Arabia, P.O. Box 7805 Riyadh 11472.
Source of Support: None, Conflict of Interest: None
Sixty ASA physical status I and II children aged 3 - 6 years were included in this study. After inhalation induction with sevoflurane, patients were randomly assigned to receive either Saline (group 1, n=20), fentanyl 1 mic /kg IV (group II, n=20) or dexmedetomidine 0.3mic/kg IV (group III, n=20)10 minutes before discontinuation of anesthetics.
There was no significant difference (p>0.05) between the three groups regarding age, weight, duration of anesthesia, duration of surgery, time to eye opening, modified Aldrete recovery scores and post operative complication.
The time of first postoperative analgesic dose was significantly shorter in group I compared with other two groups.
The incidence of agitation was significantly higher in group I compared with other two groups, the incidence of agitation was 40% in Group I, 15% in Group II and 20% in Group III. In conclusion, the dose of fentanyl 1 mic/kg iv or dexmedetomidine 0.3mic/kg iv that is administered 10 minutes before the termination of anesthesia reduces the postoperative agitation in children with no adverse effects.