ARTICLE
Year : 2007  |  Volume : 1  |  Issue : 1  |  Page : 6

Sedation characteristics of melatonin and midazolam for premedication of adult patients undergoing cataract surgery under local anaesthesia


1 Department of Anaesthesia, King Abdulaziz University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia
2 Department of Anesthesia, College of Medicine, King Saud University Hospitals, Riyadh, Saudi Arabia
3 Department of Ophthalmology, King Abdulaziz University Hospital, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Correspondence Address:
Rana Altaf Ahmad
Consultant Anaesthetist, King Abdulaziz University Hospital, P.O. Box 245, Riyadh 11411
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


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This prospective, double blind placebo controlled study is designed to compare the effects of sublingual melatonin versus midazolam for premedication of adult patients scheduled to undergo cataract surgery under local anaesthesia. Seventy five patients ASA1&2 ranged from 40-70 yr scheduled for cataract surgery procedure were studied. Patients were classified into 3 groups. Group 1 received midazolam, group 2 received melatonin and group 3 received placebo. Patients in group 1 received sublingual 0.5% midazolam solution 0.1mg/kg body weight. Group 2 received sublingual melatonin0.05mg/kg body weight. The control group received sublingual placebo (saline).All drugs were given 100 min before the local block. Sedation, anxiety and orientation were quantified before and 10, 30, 60 min after premedication and 15, 30, 60 min after admission to the recovery room. One way ANOVA and non-parametric Kurskal-wallis test were for statistical analysis. Patients who received premedication with either midazolam or melatonin had significant decrease in anxiety levels compared with control group and midazolam group significant increase in level of sedation before operation was noticed compared with melatonin and control groups (p<0.05). Midazolam produced highest scores of sedation at 30 and 60 min after administration and significant psychomotor impairment in the preoperative period compared with melatonin and placebo groups(p<0.05). Postoperative patients who no significant difference between the groups for anxiety levels or trigger dot testing performance after received midazolam, melatonin premedication showed no increase in level of sedation at all intervals. There was operation compared with control (p>0.05). Amnesia was not significant in both the groups. In conclusion, melatonin can be used effectively for premedication of adult patients without hangover effect compared to midazolam.


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